邀请报告主题

蛋白质生物材料的分析及应用

报告时间

2018.10.31 

14:00-17:00

组织单位

纤维材料改性国家重点实验室

材料科学与工程学院

报告地点

材料学院A405

报告主持人

杨升元副教授

报告人简介

Masafumi Odaka教授1994年在东京工业大学生命科学与化学系获得博士学位，1994-2003年担任理研公司（RIKEN）生化系统实验室研究员，2004年至2014年担任东京农工大学生命科学技术系副教授，2014年至今担任秋田大学生命化学系教授，现任秋田大学工程科学研究院副院长。主要研究领域为蛋白质生物材料，已在Angew. Chem. Int. Ed.，J. Am. Chem. Soc.，Nat. Struct. Biol.等国际期刊发表一系列论文。

拟报告大纲

报告题目：Over   expression and functional analyses of a protein nanocapsule, Encapsulin

摘要：Nanoparticles have been one of   the most important key technologies among various scientific fields such as   Biotechnology, Chemical Engineering, and Analytical Chemistry. Especially,   nanoparticles using gold, quantum dots, and amphiphilic polymers have been   extensively studied. Proteins are the most abundant nanomaterials in living   organisms and have been considered to have potentially very excellent   characteristics in self-organization, chemical activities and structural homogeneity.   However, studies treating proteins as nanoparticles have been very limited   except for some pioneering researches on ferritin and peripheral virus   particles, because of their complex structures, difficulties in   self-organization and/or assembly, and instability against temperature, pH   and organic solvents. We have been studied a nanoparticle-forming protein,   Encapsulin. It has a molecular weight of about 30k, and 60 copies of the   Encapsulin subunit form a spherical particle with a thin T=1 icosahedral   shell with a diameter of 24 nm (1). Here, we show two kinds of Encapsulins   from a mesophilic bacterium, Rhodococcus   erythropolis N771 and a hyperthermophilic one, Thermotoga maritima.